Stereospecific reactivation of human brain and erythrocyte acetylcholinesterase inhibited by 1,2,2-trimethylpropyl methylphosphonofluoridate (soman)

Biochim Biophys Acta. 1985 Aug 23;830(3):345-8. doi: 10.1016/0167-4838(85)90294-8.

Abstract

Human erythrocyte and brain acetylcholinesterase are preferentially inhibited by the P(-)-isomers of C(+/-)P(+/-)-soman. The enzymes inhibited by the P(-)-isomers behave similarly with respect to oxime-induced reactivation and aging. HI-6 is the best reactivator for C(+)P(-)-soman-inhibited acetylcholinesterases. Oxime-induced reactivation of the C(-)P(-)-soman-inhibited acetylcholinesterases is much more difficult to achieve.

Publication types

  • Comparative Study

MeSH terms

  • Acetylcholinesterase / metabolism*
  • Brain / enzymology*
  • Cholinesterase Inhibitors / pharmacology*
  • Cholinesterase Reactivators / pharmacology*
  • Erythrocytes / enzymology*
  • Humans
  • Kinetics
  • Organophosphorus Compounds / pharmacology*
  • Oximes / pharmacology
  • Pyridinium Compounds / pharmacology
  • Soman / pharmacology*
  • Stereoisomerism

Substances

  • Cholinesterase Inhibitors
  • Cholinesterase Reactivators
  • Organophosphorus Compounds
  • Oximes
  • Pyridinium Compounds
  • Soman
  • Acetylcholinesterase
  • asoxime chloride