Abstract
Human erythrocyte and brain acetylcholinesterase are preferentially inhibited by the P(-)-isomers of C(+/-)P(+/-)-soman. The enzymes inhibited by the P(-)-isomers behave similarly with respect to oxime-induced reactivation and aging. HI-6 is the best reactivator for C(+)P(-)-soman-inhibited acetylcholinesterases. Oxime-induced reactivation of the C(-)P(-)-soman-inhibited acetylcholinesterases is much more difficult to achieve.
MeSH terms
-
Acetylcholinesterase / metabolism*
-
Brain / enzymology*
-
Cholinesterase Inhibitors / pharmacology*
-
Cholinesterase Reactivators / pharmacology*
-
Erythrocytes / enzymology*
-
Humans
-
Kinetics
-
Organophosphorus Compounds / pharmacology*
-
Oximes / pharmacology
-
Pyridinium Compounds / pharmacology
-
Soman / pharmacology*
-
Stereoisomerism
Substances
-
Cholinesterase Inhibitors
-
Cholinesterase Reactivators
-
Organophosphorus Compounds
-
Oximes
-
Pyridinium Compounds
-
Soman
-
Acetylcholinesterase
-
asoxime chloride